In a large bowl, whisk together the buttermilk, pickle juice, garlic powder, onion powder, smoked paprika, salt, and pepper. Add the chicken fillets, ensuring they are fully submerged. Cover and refrigerate for at least 2 hours or overnight for best flavor.
In a separate bowl, combine the flour, cornstarch, paprika, garlic powder, onion powder, salt, black pepper, and baking powder. Whisk until evenly mixed.
Heat 1–2 inches of vegetable oil in a large skillet over medium-high heat to 350°F. Remove the chicken from the marinade, allowing excess to drip off, then dredge thoroughly in the seasoned flour mixture, pressing to adhere.
Fry the chicken fillets in batches for 5–6 minutes per side, until golden brown and cooked through (internal temperature reaches 165°F). Transfer to a wire rack or paper towel-lined plate to drain.
While the chicken fries, whisk together all Big Mac sauce ingredients in a bowl. Adjust seasoning to taste and set aside.
Toast all sesame seed buns, including the extra buns for the middle layer, until golden.
To assemble, spread Big Mac sauce on the bottom bun and a middle bun. Add shredded lettuce, pickle slices, and a slice of American cheese. Top with a crispy chicken fillet.
Place the middle bun on top, add more sauce, lettuce, pickles, and cheese, then add a second chicken fillet. Finish with the top bun and serve immediately.