Heat vegetable oil in a heavy pot to 350°F. While the oil heats, prepare your dredging station. In one bowl, combine flour, Creole seasoning, salt, and pepper. In a second bowl, whisk together flour, garlic powder, onion powder, Creole seasoning, salt, and pepper. Slowly add cold seltzer water until the batter reaches a thick pancake consistency.
Pat the cod fillets dry with paper towels. Lightly coat each fillet in the seasoned flour, shaking off excess. Dip into the wet batter, ensuring full coverage. Let excess batter drip off before frying.
Carefully lower each piece into the hot oil, placing it away from you. Fry for 3–4 minutes per side until deep golden brown and crisp. Flip gently for even cooking and maintain oil temperature between 350–370°F.
Remove fish and place on a wire rack to drain. Immediately top each fillet with a slice of cheese while hot so it melts slightly.
Lightly toast brioche buns if desired. Place the cheesy fish on the bottom bun and top with your favorite tartar sauce. Add the top bun and serve immediately while hot and crispy.