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This Southern-style meatloaf combines ground beef and mild Italian sausage with onion, bell pepper, garlic, and a sweet-tangy ketchup glaze. The sausage brings extra savory flavor, while breadcrumbs, milk, and eggs help the loaf hold together without turning dry.

Mix it gently, bake until the center reaches 160°F, and give it time to rest before slicing. It is a hearty Sunday dinner that also makes useful leftovers for the next day.

🍽️ A Quick Look at the Recipe

Recipe Name: Southern-Style Meatloaf

⏱️ Ready In: About 1 hour 25 minutes, including resting

👨‍👩‍👧‍👦 Serves: 6

🥣 Main Ingredients: Ground beef, mild Italian sausage, breadcrumbs, eggs, ketchup

📖 Dietary Info: Contains wheat, eggs, and dairy; check sausage and seasoning labels

🔥 Flavor Profile: Savory, gently spiced, and sweet-tangy

⭐ Best For: Sunday dinner, family meals, and leftovers

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Why You’ll Love This Recipe

  • Beef and mild Italian sausage give the meatloaf a full, savory flavor.
  • Onion, peppers, garlic, and parsley keep the flavor varied throughout the loaf.
  • The glaze goes on partway through baking so it can set without spending the entire bake in the oven.
  • A short rest helps you cut neater slices and keep the juices in the meatloaf.

Key Ingredients

Ground beef and mild Italian sausage: The original recipe uses 80/20 beef alongside sausage. Keep that combination for the closest result; very lean meat changes the texture and moisture.

Onion, bell peppers, and garlic: Dice the vegetables finely so they distribute through the loaf and soften during baking. Large chunks can leave gaps and make the slices less tidy.

Panko or crushed crackers: These absorb moisture and help bind the mixture. The card allows either option; if using crackers, consider their salt content before adjusting the finished meal.

Milk and eggs: Milk moistens the crumbs, and eggs help the loaf set. Keep the recipe’s balance instead of adding extra breadcrumbs just because the raw mixture feels soft.

Creole Kick or Cajun seasoning, paprika, and parsley: These bring the Southern-style flavor. Preserve the seasoning choice and amounts in the card; sausage and seasoning blends already contribute salt.

Ketchup glaze: Ketchup, brown sugar, vinegar, garlic powder, onion powder, salt, and pepper create the sweet-tangy coating. Mix it separately and brush it on after the first part of the bake.

A wooden table displays all you need for the best meatloaf recipe: ground beef, Italian sausage, eggs, milk, bell peppers, onion, garlic, seasonings, ketchup, breadcrumbs, salt in a wooden container, and a pepper grinder.
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Useful Tools

Use a meatloaf pan or form the loaf on a rimmed baking sheet, as the original recipe allows. A rimmed pan catches drippings; a large mixing bowl lets you combine the ingredients without squeezing them together too tightly.

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How to Make Southern-Style Meatloaf

1. Heat the oven and prep the vegetables

Preheat to 375°F. Finely dice the onion and bell peppers, mince the garlic, and chop the parsley so everything is ready before you handle the meat.

2. Mix gently

Combine the ground beef, sausage, onion, peppers, eggs, garlic, ketchup, parsley, panko or crackers, milk, and meatloaf seasonings in a large bowl. Mix just until the ingredients are evenly distributed; avoid kneading or compressing the mixture.

3. Shape the loaf

Transfer the mixture to a meatloaf pan or form it into a loaf on a rimmed baking sheet. Keep the shape even so the center and ends cook at a similar pace. Wash hands, utensils, and work surfaces after handling the raw meat.

4. Make the glaze and begin baking

In a separate bowl, stir together the glaze ingredients. Bake the meatloaf uncovered for 40 minutes before adding the glaze.

5. Glaze and finish cooking

Carefully remove the pan, brush the glaze over the top, and return it to the oven for another 15–20 minutes. Check the thickest part of the loaf for at least 160°F. If it has not reached that temperature, keep baking and check again.

6. Rest before slicing

Let the finished meatloaf rest for 10 minutes. Transfer or lift it carefully, then slice with a clean knife and serve. The rest gives the loaf time to firm up so the slices hold together better.

Pro Tips

  • Dice the onion and peppers finely so they soften evenly and do not create large gaps in the loaf.
  • Mix only until combined; compacting the meat mixture can make the finished loaf dense.
  • Use a thermometer to reach 160°F, then rest for 10 minutes before slicing.

Homemade Meatloaf

5 from 4 votes
Prep: 15 minutes
Cook: 1 hour
Resting Time: 10 minutes
Total: 1 hour 25 minutes
Servings: 6
When you talk about comfort food, few dishes stand as tall as a classic homemade meatloaf. We going back to the basics on this one – by popular demand. This is that hearty, flavorful, straight-from-the-heart type of dish that’ll make you feel like you’re back in grandma’s kitchen. This ain’t just meatloaf – this is soul food wrapped in a pan.
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Ingredients  

  • Meatloaf:
  • 1 lbs ground beef 80/20
  • 1 lb Italian mild sausage
  • 1 medium onion finely diced
  • 1/2 red bell pepper diced
  • 1/2 green bell pepper diced
  • 2 eggs
  • 3 garlic cloves minced
  • 3 tbsp ketchup
  • 3 tbsp fresh parsley chopped
  • 3/4 cup panko breadcrumbs or crushed crackers
  • 1/3 cup milk
  • 1 ½ tsp salt
  • 1 ½ tsp Creole Kick or Cajun seasoning
  • 1/2 tsp black pepper
  • 1/2 tsp paprika
  • Glaze:
  • 3/4 cup ketchup
  • 1 ½ tsp white vinegar
  • 2 ½ tbsp brown sugar
  • 1 tsp garlic powder
  • 1/2 tsp onion powder
  • 1/2 tsp black pepper
  • 1/2 tsp salt

Instructions 

  • Preheat oven to 375°F.
  • In a large bowl, combine all meatloaf ingredients. Mix until just combined — don’t overmix.
  • Press mixture into a meatloaf pan or form into a loaf on a baking sheet.
  • In a separate bowl, mix together all glaze ingredients.
  • Bake meatloaf uncovered for 40 minutes.
  • Remove from oven, brush glaze generously on top.
  • Return to oven and bake for 15–20 more minutes, or until internal temperature reaches 160°F.
  • Let rest for 10 minutes before slicing. Serve and enjoy.

Notes

  • Mix the meat just until the ingredients come together; overworking it makes a denser loaf.
  • Check the center with a thermometer and cook to 160°F rather than relying on color.
  • Rest the loaf for 10 minutes before slicing so it holds together.
Nutrition is estimated for one-sixth of the loaf and glaze using 80/20 beef, mild pork Italian sausage, whole milk, Kikkoman panko and Tony Chachere’s Original Creole Seasoning for the Cajun seasoning option. All listed salt, glaze and meat fat are counted; discarded drippings reduce the amount eaten. Brands and seasoning choices change the estimate.

Nutrition

Calories: 550kcal | Carbohydrates: 29g | Protein: 28g | Fat: 36g | Saturated Fat: 13g | Cholesterol: 170mg | Sodium: 1980mg | Fiber: 1g | Sugar: 17g

Nutrition information is automatically calculated, so should only be used as an approximation.

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Make-Ahead, Storage, and Reheating

Dice the vegetables and mix the glaze ahead, then refrigerate them separately. If assembling the raw loaf ahead, keep it covered at 40°F or below and cook within 1–2 days, following any earlier use-by date on the meat.

Refrigerate cooked meatloaf in shallow containers within 2 hours, or within 1 hour if the surrounding temperature is above 90°F. Use cooked leftovers within 3–4 days.

Reheat slices covered in a 325°F oven until they reach 165°F. Add a splash of broth or water to the dish if needed to keep the edges from drying. The microwave works for individual slices; turn or rearrange them so they heat evenly.

Freeze cooled portions in airtight wrapping for longer storage. Thaw in the refrigerator and reheat thoroughly. Slicing before freezing makes it easier to warm only what you need.

What to Serve With Southern-Style Meatloaf

Pair the savory loaf with a vegetable and a comforting side. These recipes give you options for a weeknight plate or a bigger Sunday spread.

Variations and Alternate Dinners

The source already allows crushed crackers instead of panko and Cajun seasoning instead of Creole Kick. Keep the listed amounts and be mindful of differences in salt between brands.

For a different comfort-food dinner, follow one of these separate recipes rather than changing this loaf’s meat and binder balance:

Frequently Asked Questions

Why use both beef and sausage?

The beef gives the loaf its familiar flavor, while mild Italian sausage adds seasoning and richness. Replacing either with very lean meat changes the original balance.

Can I tell it is done from the color?

No. Check the center with a food thermometer. This beef-and-pork mixture needs to reach at least 160°F, regardless of how brown the outside looks.

Why does meatloaf sometimes fall apart?

The binders need to be evenly mixed, the loaf needs to cook through, and it needs its resting time. Cutting immediately out of the oven can break apart a loaf that would slice more cleanly after resting.

Is a loaf pan required?

No. The original method allows a meatloaf pan or a loaf formed on a baking sheet. Use a rimmed sheet to contain drippings and keep the thickness reasonably even.

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Save this recipe for the next time you want a hearty meatloaf dinner with a sweet-tangy glaze and slices that hold together.

About AB

Aaron “A.B.” Brown, a self-taught culinary maestro, has carved his flavorful path into the hearts and kitchens of millions. With over 3.6 million devoted YouTube subscribers, he’s become a household name for those seeking culinary expertise.

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5 from 4 votes

4 Comments

  1. Kathy Woodard says:

    5 stars
    Like ingredients and it’s home made

  2. You says:

    5 stars
    Thx

  3. Andre says:

    5 stars
    In the words of JJ Evans, DYNAMITE!!!!! This is a great meal for the week that leaves great leftovers to take to work!!!

  4. Amanda says:

    5 stars
    This is the BEST meatloaf recipe I’ve ever made. It’s so moist and flavorful! Thank you!! 10/10!